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KMID : 0624620130460040195
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BMB Reports
2013 Volume.46 No. 4 p.195 ~ p.200
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Accelerating repaired basement membrane after bevacizumab treatment on alkali-burned mouse cornea
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Lee Koon-Ja
Lee Ji-Young
Lee Sung-Ho
Choi Tae-Hoon
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Abstract
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To understand the corneal regeneration induced by bevacizumab, we investigated the structure changes of stroma and basement membrane regeneration. A Stick soaked in 0.5 N NaOH onto the mouse cornea and 2.5 mg/ml of bevacizumab was delivered into an alkali-burned cornea (2 μl) by subconjunctival injections at 1 hour and 4 days after injury. At 7 days after injury, basementmembrane regeneration was observed by transmission electron microscope. Uneven and thin epithelial basement membrane, light density of hemidesmosomes, and edematous collagen fibril bundles are shown in the alkali-burned cornea. Injured epithelial basement membrane and hemidesmosomes and edematous collagen fibril bundles resulting from alkali-burned mousecornea was repaired by bevacizumab treatment. This study demonstrates that bevacizumab can play an important role in wound healing in the cornea by accelerating the reestablishment ofbasement membrane integrity that leads to barriers for scar formation.
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KEYWORD
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Alkali-burned cornea, Basement, Bevacizumb membrane, Regeneration, Wound healing
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